Description

Computational Biologist 2

US-OR-Portland

Requisition ID: 2025-36815
Position Category: Research
Job Type: Research
Position Type: Regular Full-Time
Posting Department: Knight Diagnostics Lab - Knight Cancer Institute
Posting Salary Range: $81,619 - $130,374 per year with offer based on experience, education and internal equity
Posting FTE: 1.00
Posting Schedule: Monday through Friday
Posting Hours: 8:30am to 5:00pm plus occasional nights and weekends
HR Mission: School of Medicine
Drug Testable: No

Department Overview
The OHSU Knight Cancer Institute is internationally recognized for pioneering advances in personalized cancer treatment and early detection. From transforming Chronic Myeloid Leukemia with Gleevec to driving precision oncology, the institute is dedicated to ending cancer as we know it. Our culture is guided by three principles: we are bold, we are supportive, and we work as a connected team. The Knight Diagnostic Laboratories (KDL) is a CLIA/CAP-accredited diagnostic laboratory with decades of expertise in molecular oncology, rare genetic disorders, and cytogenetics. Our team of medical directors, scientists, and technical specialists provide cutting-edge diagnostic testing to enable personalized medicine. Additionally, through close partnerships with the Knight BioLibrary and Histopathology Shared Resource Laboratories, our clients can also gain access to biospecimens, histology, and immunohistochemistry services. Every Knight Cancer employee is expected to embody our guiding principles: 

We act BOLDLY—Breakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differentlyWe SUPPORT each other—Respect leads to trust, which leads to excellenceWe work as a CONNECTED team—We must leverage our collective brain power to conquer cancer because no one individual can do it alone

Function/Duties of Position
Position Summary - We are seeking a Computational Biologist / Clinical Bioinformatician to join our multidisciplinary team. This role provides bioinformatics expertise in support of clinical test development and will work closely with medical directors, bioinformaticians, and wet-lab scientists to develop, validate, and maintain clinical workflows in accordance with CAP and regulatory standards. The successful candidate will bring strong experience in next-generation sequencing (NGS) data processing and analysis (tissue, blood, and cell-free specimens; OR: DNA, RNA, epigenomics), and bioinformatics tool development and biostatistics, with a commitment to teamwork, reproducibility, and clinical best practices. Key Responsibilities:

• Support clinical test development through computational analysis of data and development of computational tools.
• Develop, validate, and maintain bioinformatics pipelines aligned with CAP/CLIA requirements.
• Implement and benchmark tools, algorithms, and workflows for variant calling, expression analysis, and proteomic profiling.
• Collaborate with medical directors, clinical bioinformatics teams, and wet bench scientists in a cross-disciplinary environment.
• Contribute to SOP-driven analysis workflows, ensuring reproducibility and regulatory compliance.
• Manage and maintain code, data, and version control repositories (e.g., GitHub).
• Provide bioinformatics support for clinical reporting and test development.
• Stay current with emerging literature, methods, and tools in computational biology and clinical bioinformatics.
• Participates in the supervision of trainees involved in computational projects

Required Qualifications

• Master's Degree in Computational Biology or related field AND 3 years of relevant experience OR Bachelor's Degree in Computational Biology or related field AND 6 years of relevant experience
• 1 year of clinical experience in NGS data analysis including variant calling, copy number analysis and structural variant interpretation
• 1 year of clinical Bioinformatics Tools & Pipelines:  Alignment (BWA, STAR, HISAT2); Variant callers (Mutect2, VarScan, Strelka, FreeBayes); Annotation tools (ANNOVAR, VEP, Oncotator); Workflow management (Nextflow, Snakemake, WDL/Cromwell)
• Demonstrated ability to develop genomic analysis workflows.
• Demonstrated skills in a high-level programming language, preferably Python or R, Pearl, preferably in Linux or Unix, optionally with Java or C/C++
• Experience with artificial intelligence methods.
• Experience with SOP-driven workflows for reproducibility and accreditation compliance
• Experience with statistics and its applications to data analysis and interpretation
• Experience with structured data storage and with multi-component data processing systems
• Experience with architecture or tools for managing "omics" or imaging data
• Ability to prioritize multiple tasks at one time
• Excellent communication, analytical and organizational skills:  both written and verbal
• Ability to work independently and as part of a team while being collaborative in resolving problems
• Intermediate skills with Microsoft Office (Excel, Outlook, Access, Word, and PowerPoint) on Window OS. Ability to accurately type 60wpm
• Working knowledge of Oracle
• Must have demonstrated excellent customer service skills both on the phone and in person
• Must possess energy and drive to coordinate multiple projects simultaneously
• Ability to use tact and diplomacy to maintain effective working relationships

Preferred Qualifications

• PhD in Computational Biology or related field
• Experience as a data analyst, data scientist, software developer or biostatistician, including at least 6 months in a collaborative teamwork environment.
• Clinical report generation
• Experience with AWS data workflows
• Familiarity with CLIA/CAP regulations for molecular diagnostics
• High-performance computing experience
• Experience developing, training, and implementing AI-based tools.

Additional Details
Apply online. Please be sure to upload a Cover Letter and Resume/CV.  We offer a variety of benefits on top of joining a thriving organization:

Medical, dental and vision coverage at no or low cost to employees
Covered 100% for full-time employees and 88% for dependents
Several retirement plans to choose from with contributions from OHSU25 days a year of paid time off8 days of sick time off Commuter subsidiesTuition reimbursementAccess to group life insurance, disability insurance and other supplemental benefitsAnnual Merit IncreaseGrowth/Development OpportunitiesEmployee discounts to local and major businesses

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All are welcome
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.

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